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Article Dans Une Revue Nature Neuroscience Année : 2007

Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels

Résumé

The hair cell's mechanoreceptive organelle, the hair bundle, is highly sensitive because its transduction channels open over a very narrow range of displacements. The synchronous gating of transduction channels also underlies the active hair-bundle motility that amplifies and tunes responsiveness. The extent to which the gating of independent transduction channels is coordinated depends on how tightly individual stereocilia are constrained to move as a unit. Using dual-beam interferometry in the bullfrog's sacculus, we found that thermal movements of stereocilia located as far apart as a bundle's opposite edges display high coherence and negligible phase lag. Because the mechanical degrees of freedom of stereocilia are strongly constrained, a force applied anywhere in the hair bundle deflects the structure as a unit. This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs.
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Dates et versions

hal-00961026 , version 1 (03-01-2017)

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Andrei S. Kozlov, Thomas Risler, A. J. Hudspeth. Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels. Nature Neuroscience, 2007, 10 (1), pp.87-92. ⟨10.1038/nn1818⟩. ⟨hal-00961026⟩
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