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Communication Dans Un Congrès Année : 2022

Nanoengineering and Therapeutic Evaluation of a novel bioorganoMetallic complex with high potent antitumor activity for Ovarian Cancer

Résumé

Ovarian cancer is one the deadliest epithelial malignancy in women because of multidrug resistances affecting the success of traditional chemotherapies like carboplatin and paclitaxel [1]. High grade serous ovarian carcinoma (HGSOV) can be classified in two subtypes, the High OXPHOS tumor that is chemosensitive, and the Low OXPHOS tumor that is chemoresistant [2]. The difference of sensitivity could come from the redox status of these tumors. Ferrocifens, bio-organometallic compounds, are considered as ROS producers with good cytotoxicity on multi-drug resistant cancer cell lines like ovarian cancer [3]. Nevertheless, to be administered in vivo, nanocarriers as the lipid nanocapsules (LNCs) are needful because of their hydrophobic nature [3]. The aim of this study was to evaluate the in vivo efficiency of ferrocifen lipid nanocapsules (LNCs) on a Low OXPHOS ovarian cancer Patient-Derived-Xenograft (PDX) model, alone or in combination to standard chemotherapies (carboplatin and paclitaxel). Concretely, two ferrocifens, P53 and P722, were encapsulated into 50 nm monodisperse LNCs. The surface of LNCs was decorated with a PEGylated phospholipid, DSPE-PEG2000, in order to confer stealth properties to the nanovectors. Stealth P722 LNCs in combination with chemotherapies showed higher tumor reduction than the combination with stealth P53 LNCs on a Low OXPHOS model compared to standard chemotherapie (54 % of variation and 29 % of variation respectively). These results showed that combining standard chemotherapies, carboplatin and paclitaxel, with stealth P722 LNCs could be a promising approach to treat resistant ovarian adenocarcinoma compared to chemotherapies alone.
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Présentation Cancéropôle Grand Ouest_Mai2022.pdf (1.67 Mo) Télécharger le fichier
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Dates et versions

hal-04107696 , version 1 (30-05-2023)

Identifiants

  • HAL Id : hal-04107696 , version 1

Citer

Pierre Idlas, Abdallah Ladaycia, Fariba Némati, Elise Lepeltier, Gérard Jaouen, et al.. Nanoengineering and Therapeutic Evaluation of a novel bioorganoMetallic complex with high potent antitumor activity for Ovarian Cancer. Journées Scientifiques du Cancéropôle Grand Ouest, Réseau Vectorisation, Imagerie, Radiothérapies, May 2022, Rennes, France. ⟨hal-04107696⟩
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