Ilf3 and NF90 functions in RNA biology - Biologie de l'ovocyte Accéder directement au contenu
Article Dans Une Revue WILEY INTERDISCIPLINARY REVIEWS-RNA Année : 2015

Ilf3 and NF90 functions in RNA biology

Sandrine Castella
  • Fonction : Auteur
Rozenn Bernard
Aurelie Fradin
  • Fonction : Auteur
Jean-Christophe Larcher
  • Fonction : Auteur

Résumé

Double-stranded RNA-binding proteins (DRBPs) are known to regulate many processes of RNA metabolism due, among others, to the presence of double-stranded RNA (dsRNA)-binding motifs (dsRBMs). Among these DRBPs, Interleukin enhancer-binding factor 3 (Ilf3) and Nuclear Factor 90 (NF90) are two ubiquitous proteins generated by mutually exclusive and alternative splicings of the Ilf3 gene. They share common N-terminal and central sequences but display specific C-terminal regions. They present a large heterogeneity generated by several post-transcriptional and post-translational modifications involved in their subcellular localization and biological functions. While Ilf3 and NF90 were first identified as activators of gene expression, they are also implicated in cellular processes unrelated to RNA metabolism such as regulation of the cell cycle or of enzymatic activites. The implication of Ilf3 and NF90 in RNA biology will be discussed with a focus on eukaryote transcription and translation regulation, on viral replication and translation as well as on noncoding RNA field. WIREs RNA 2015, 6:243-256. doi: 10.1002/wrna.1270 For further resources related to this article, please visit the . Conflict of interest: The authors have declared no conflicts of interest for this article.

Dates et versions

hal-01538510 , version 1 (13-06-2017)

Identifiants

Citer

Sandrine Castella, Rozenn Bernard, Melanie Corno, Aurelie Fradin, Jean-Christophe Larcher. Ilf3 and NF90 functions in RNA biology. WILEY INTERDISCIPLINARY REVIEWS-RNA, 2015, 6 (2), pp.243-256. ⟨10.1002/wrna.1270⟩. ⟨hal-01538510⟩
87 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More