Maternal mRNAs with distinct 3′ UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation - Biologie de l'ovocyte Accéder directement au contenu
Article Dans Une Revue Genes and Development Année : 2017

Maternal mRNAs with distinct 3′ UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation

Ye Yang
  • Fonction : Auteur
Cai-Rong Yang
  • Fonction : Auteur
Seung Jin Han
  • Fonction : Auteur
Enrico Maria Daldello
Ara Cho
  • Fonction : Auteur
Joao Martins
  • Fonction : Auteur
Guoliang Xia
  • Fonction : Auteur
Marco Conti
  • Fonction : Auteur

Résumé

The final stages of female gamete maturation occur in the virtual absence of transcription, with gene expression driven by a program of selective unmasking, translation, and degradation of maternal mRNAs. Here we demonstrate that the timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the presence of transcripts with different 3′ untranslated regions (UTRs). This 3′ UTR heterogeneity directs distinct temporal patterns of translational activation or repression. Inclusion or exclusion of cis -acting elements is responsible for these divergent regulations. Our findings reveal an additional layer of translation control through alternative polyadenylation usage required to fine-tune the timing of meiosis progression.

Dates et versions

hal-03989288 , version 1 (14-02-2023)

Identifiants

Citer

Ye Yang, Cai-Rong Yang, Seung Jin Han, Enrico Maria Daldello, Ara Cho, et al.. Maternal mRNAs with distinct 3′ UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation. Genes and Development, 2017, 31 (13), pp.1302-1307. ⟨10.1101/gad.296871.117⟩. ⟨hal-03989288⟩
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