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Article Dans Une Revue Diagnostic Microbiology and Infectious Disease Année : 2017

Kinetics of biofilm formation by Staphylococcus lugdunensis strains in bone and joint infections

Résumé

OBJECTIVE: To describe the clinical presentation and 1-year follow-up of patients with bone and joint infections (BJIs) caused by Staphylococcus lugdunensis and evaluate its biofilm-forming capacities. PATIENTS AND METHODS: Overall, 28 patients with BJIs from VISLISI clinical trials were included. We evaluated 1-year clinical follow-up and analyzed biofilm production kinetics of the 28 strains using the BioFilm Ring Test®. RESULTS: Of all patients, 12 had osteoarticular infections without material and 16 had prosthetic joint infections, of which 9 underwent a 1-stage revision procedure. At the 1-year follow-up, all patients were cured but needed a surgical intervention. Diabetes affected 46.4% of all patients. Of all, 20 strains (71.4%) started biofilm formation within 2 h, but all strains started the formation after 4 h experiment, and 25 strains (89.3%) reached a maximum after 6 h. CONCLUSIONS: This study describes the clinical and surgical management of BJIs caused by S. lugdunensis and shows that 1-stage prosthesis exchange procedures may be efficient. Further, It shows that biofilm production by this strain was not marginal and directly impacted clinical and surgical management.

Dates et versions

hal-02932830 , version 1 (07-09-2020)

Identifiants

Citer

Xavier Argemi, Gilles Prevost, Philippe Riegel, Christian Provot, Stéphanie Badel-Berchoux, et al.. Kinetics of biofilm formation by Staphylococcus lugdunensis strains in bone and joint infections. Diagnostic Microbiology and Infectious Disease, 2017, 88 (4), pp.298-304. ⟨10.1016/j.diagmicrobio.2017.05.002⟩. ⟨hal-02932830⟩

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