Acetylcholinesterase knockout mouse Dystrophie Myotonique Thérapie génique Glutamate Myotonic Dystrophy Type 1 DM1 Centronuclear myopathy Hypoxia Astrocyte DMPK Male ACETYLCHOLINESTERASE Therapy Long read sequencing Oligodendrocytes Glucocorticoid-receptor MBNL Humans Gene editing KNOCKOUT MICE Transcriptomics Astrocytes Animals Intermediate filament Oligodendrocyte Cell model Exercice Skeletal muscle RNA interference Dystrophin Motoneuron CMS DMSXL mice Trinucleotide Repeat Expansion Acute coronary syndrome Gene Therapy Mouse model Quantitative microdialysis Autophagy Maximal force Diaphragm Mice Duchenne muscular dystrophy Central nervous system Fibrosis Heart Knockout Acetylcholinesterase deficiency BIOLOGIE MOLECULAIRE Mouse models Heart failure RNA splicing Myotonic Dystrophy CTG repeat instability Cardiac muscle Muscle In vivo Muscular dystrophy Alternative splicing Expression Glucocorticoids Dilated cardiomyopathy Exercise Brain dysfunction Transgenic mouse model Gene therapy Dystrophie myotonique Cell culture model AAV CTG repeats Myotonic dystrophy mouse models PCR Myotonic Dystrophy type 1 Aging Myotonic dystrophy GABA GSK3␤ Cytoskeleton Transgenic mouse CTG repeat contractions Trinucleotide repeat expansion PacBio Neuron RNA biology Dynamin 2 CRISPRi CRISPR/Cas9 ARN Antisense oligonucleotide Endurance training Glial cells Antisense oligonucleotides Brain Cell penetrating peptide Myostatin Myelin CONGENITAL MYATHENIC SYNDROME Desmin Myotonic dystrophy type 1 Genotype phenotype correlation