Anion conductance of the human red cell is carried by a maxi-anion channel. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Blood Cells, Molecules and Diseases Année : 2010

Anion conductance of the human red cell is carried by a maxi-anion channel.

Edyta Glogowska
  • Fonction : Auteur
Agnieszka Dyrda
  • Fonction : Auteur
Anne Cueff
  • Fonction : Auteur
Guillaume Bouyer
Stéphane Egée
  • Fonction : Auteur
Poul Bennekou
  • Fonction : Auteur
Serge L y Thomas
  • Fonction : Auteur correspondant
  • PersonId : 857576

Connectez-vous pour contacter l'auteur

Résumé

Historically, the anion transport through the human red cell membrane has been perceived to be mediated by Band 3, in the two-component concept with the large electroneutral anion exchange accompanied by the conductance proper, which dominated the total membrane conductance. The status of anion channels proper has never been clarified, and the informations obtained by different groups of electrophysiologists are rather badly matched. This study, using the cell-attached configuration of the patch-clamp technique, rationalizes and explains earlier confusing results by demonstrating that the diversity of anionic channel activities recorded in human erythrocytes corresponds to different kinetic modalities of a unique type of maxi-anion channel with multiple conductance levels and probably multiple gating properties and pharmacology, depending on conditions. It demonstrates the role of activator played by serum in the recruitment of multiple new conductance levels showing very complex kinetics and gating properties upon serum addition. These channels, which seem to be dormant under normal physiological conditions, are potentially activable and could confer a far higher anion conductance to the red cell than the ground leak mediated by Band 3.

Dates et versions

hal-00486393 , version 1 (25-05-2010)

Identifiants

Citer

Edyta Glogowska, Agnieszka Dyrda, Anne Cueff, Guillaume Bouyer, Stéphane Egée, et al.. Anion conductance of the human red cell is carried by a maxi-anion channel.. Blood Cells, Molecules and Diseases, 2010, 44 (4), pp.243-51. ⟨10.1016/j.bcmd.2010.02.014⟩. ⟨hal-00486393⟩
42 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More