Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue World Journal of Gastroenterology Année : 2010

Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.

Résumé

AIM: To evaluate whether crypt abscesses from inflammatory bowel disease (IBD) patients contain bacteria and to establish their nature. METHODS: We studied 17 ulcerative colitis patients, 11 Crohn's disease patients, 7 patients with acute self-limited colitis (ASLC) and normal colonic biopsies from 5 subjects who underwent colonoscopy for colon cancer screening. A fluorescent in situ hybridization technique was applied to colonic biopsies to assess the microbiota composition of the crypts and crypt abscesses. RESULTS: Crypts colonized by bacteria were observed in 42.9% and 3.6% of ASLC and IBD patients, respectively (P = 0.019). Crypt abscesses colonized by bacteria were observed in 28.6% and 0.0% of ASLC and IBD patients, respectively (P = 0.035). CONCLUSION: These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts.

Domaines

Chimie organique
Fichier non déposé

Dates et versions

hal-00599129 , version 1 (08-06-2011)

Identifiants

  • HAL Id : hal-00599129 , version 1
  • PUBMED : 20128026

Citer

Harry Sokol, Nadia Vasquez, Nadia Hoyeau-Idrissi, Philippe Seksik, Laurent Beaugerie, et al.. Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.. World Journal of Gastroenterology, 2010, 16 (5), pp.583-7. ⟨hal-00599129⟩
70 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More