Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2013

Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.

Résumé

Neuronal activity regulates the phosphorylation states at multiple sites on MeCP2 in postmitotic neurons. The precise control of the phosphorylation status of MeCP2 in neurons is critical for the normal development and function of the mammalian brain. However, it is unknown whether phosphorylation at any of the previously identified sites on MeCP2 can be induced by signals other than neuronal activity in other cell types, and what functions MeCP2 phosphorylation may have in those contexts. Here we show that in neural progenitor cells isolated from the adult mouse hippocampus, cell cycle-linked phosphorylation at serine 421 on MeCP2 is directly regulated by aurora kinase B and modulates the balance between proliferation and neural differentiation through the Notch signalling pathway. Our findings suggest MeCP2 S421 phosphorylation may function as a general epigenetic switch accessible by different extracellular stimuli through different signalling pathways for regulating diverse biological functions in different cell types.

Domaines

Chimie organique

Dates et versions

hal-01087949 , version 1 (27-11-2014)

Identifiants

Citer

Hongda Li, Xiaofen Zhong, Kevin F Chau, Nicholas J Santistevan, Weixiang Guo, et al.. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.. Nature Communications, 2013, 5, pp.5601. ⟨10.1038/ncomms6601⟩. ⟨hal-01087949⟩
234 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More