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Article Dans Une Revue Journal of Organometallic Chemistry Année : 2005

Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes

Résumé

The preparation of a variety of chiral N-heterocyclic carbene (NHC) precursors is described. The relative merits of imidazolinium salts and silver carbenes as NHC precursors are discussed with respect to their synthesis, stability and performance in the copper catalysed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors. Enantioselectivities of up to 93% were achieved using as little as 4% of chiral ligand. (c) 2005 Elsevier B.V. All rights reserved.

Dates et versions

hal-01147004 , version 1 (29-04-2015)

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Caroline L. Winn, F. Guillen, Julien Pytkowicz, Sylvain Roland, Pierre Mangeney, et al.. Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes. Journal of Organometallic Chemistry, 2005, 690 (24-25), pp.5672. ⟨10.1016/j.jorganchem.2005.07.024⟩. ⟨hal-01147004⟩
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