A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis An inherited maternal signal causes H3K9me3 deposition at piRNA-producing regions A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2014

A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis An inherited maternal signal causes H3K9me3 deposition at piRNA-producing regions A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis

Résumé

Piwi-interacting (pi)RNAs repress diverse transposable elements in germ cells of Metazoa and are essential for fertility in both invertebrates and vertebrates. The precursors of piRNAs are transcribed from distinct genomic regions, the so-called piRNA clusters; however, how piRNA clusters are differentiated from the rest of the genome is not known. To address this question, we studied piRNA biogenesis in two D. virilis strains that show differential ability to generate piRNAs from several genomic regions. We found that active piRNA biogenesis correlates with high levels of histone 3 lysine 9 trimethylation (H3K9me3) over genomic regions that give rise to piRNAs. Furthermore, piRNA biogenesis in the progeny requires the transgenerational inheritance of an epigenetic signal, presumably in the form of homologous piRNAs that are generated in the maternal germline and deposited into the oocyte. The inherited piRNAs enhance piRNA biogenesis through the installment of H3K9me3 on piRNA clusters.
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hal-01311708 , version 1 (04-05-2016)

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Adrien Le Thomas, Georgi K. Marinov, Alexei A. Aravin. A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis An inherited maternal signal causes H3K9me3 deposition at piRNA-producing regions A Transgenerational Process Defines piRNA Biogenesis in Drosophila virilis. Cell Reports, 2014, 8 (6), pp.1617-1623. ⟨10.1016/j.celrep.2014.08.013⟩. ⟨hal-01311708⟩
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