Expression Analysis of the Stem Cell Marker <i>Pw1/Peg3</i> Reveals a CD34 Negative Progenitor Population in the Hair Follicle - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Stem Cells Année : 2017

Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle

Résumé

Pw1/Peg3 is a parentally imprinted gene expressed in adult stem cells in every tissue thus far examined including the stem cells of the hair follicle. Using a Pw1/Peg3 reporter mouse, we carried out a detailed dissection of the stem cells in the bulge, which is a major stem cell compartment of the hair follicle in mammalian skin. We observed that PW1/Peg3 expression initiates upon placode formation during fetal development, coincident with the establishment of the bulge stem cells. In the adult, we observed that PW1/Peg3 expression is found in both CD34+ and CD34- populations of bulge stem cells. We demonstrate that both populations can give rise to new hair follicles, reconstitute their niche, and self-renew. These results demonstrate that PW1/Peg3 is a reliable marker of the full population of follicle stem cells and reveal a novel CD34- bulge stem-cell population. Stem Cells 2017;35:1015–1027
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Dates et versions

hal-01515292 , version 1 (27-04-2017)

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Vanessa Besson, Sergiy Kyryachenko, Peggy Janich, Salvador A. Benitah, Giovanna Marazzi, et al.. Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle. Stem Cells, 2017, 35 (4), pp.1015-1027. ⟨10.1002/stem.2540⟩. ⟨hal-01515292⟩
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