Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Mammalian Genome Année : 1994

Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence

Résumé

The Xist sequence has several characteristics that make it a potential candidate for the X-inactivation center. To investigate the role of Xist and adjacent sequences lying within the X-inactivation center candidate region, a 460-kb region surrounding the murine Xist sequence has been arrayed in lambda contigs with a combination of IRS-PCR-based hybridization and YAC fragmentation. The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human.

Dates et versions

hal-02090228 , version 1 (04-04-2019)

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Citer

C. Rougeulle, Laurence Colleaux, B. Dujon, Philip Avner. Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence. Mammalian Genome, 1994, 5 (7), pp.416-423. ⟨10.1007/BF00357001⟩. ⟨hal-02090228⟩
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