On the estimation of the pseudo-stoichiometric matrix for macroscopic mass balance modelling of biotechnological processes - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Mathematical Biosciences Année : 2005

On the estimation of the pseudo-stoichiometric matrix for macroscopic mass balance modelling of biotechnological processes

Résumé

In this paper we propose a methodology to determine the structure of the pseudo-stoichiometric coefficient matrix $ \kappa$ in a macroscopic mass balance based model. The first step consists in estimating the minimal number of reactions that must be taken into account to represent the main mass transfer within the bioreactor. This provides the dimension of $ \kappa$. Then we discuss the identifiability of the components of $ \kappa$ and we propose a method to estimate their values. Finally we present a method to select among a set of possible macroscopic reaction networks those which are in agreement with the available measurements. These methods are illustrated with 3 examples: real data of the growth and biotransformation of the filamentous fungi {\it Pycnoporus cinnabarinus}, real data of an anaerobic digester involving a bacterial consortium degrading a mixture of organic substrates and a process of lipase production from olive oil by {\it Candida rugosa}.
Fichier principal
Vignette du fichier
BernardBastinMBS6448.pdf (3.84 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inria-00122545 , version 1 (03-01-2007)

Identifiants

  • HAL Id : inria-00122545 , version 1

Citer

Olivier Bernard, Georges Bastin. On the estimation of the pseudo-stoichiometric matrix for macroscopic mass balance modelling of biotechnological processes. Mathematical Biosciences, 2005, 193, pp.51-77. ⟨inria-00122545⟩
238 Consultations
341 Téléchargements

Partager

Gmail Facebook X LinkedIn More