Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber - ENSTA Paris - École nationale supérieure de techniques avancées Paris Accéder directement au contenu
Communication Dans Un Congrès Proc. SPIE 7893 Année : 2011

Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber

Claire Lefort
Nicolas Sandeau
  • Fonction : Auteur
Tigran Mansuryan
  • Fonction : Auteur
  • PersonId : 920960
Frédéric Louradour
Sergei Kruglik
Geneviève Bourg-Heckly
  • Fonction : Auteur

Résumé

We are developing a non-linear fibered endomicroscope for imaging the extracellular matrix collagen and elastin fibrillar networks during bronchoscopy. As a proof of concept, laser pulses at the output of a standard 2 meter long single-mode fibre have been obtained with pulse duration of about 50 fs and pulse energy up to 50 uJ, using a specially designed grism line for the dispersion compensation. With these pulses, we performed a spectroscopic characterization of the non-linear endogenous signal, consisting of two-photon fluorescence and second harmonic generation, and originated from human pulmonary tissue of various thickness, both in forward and backward geometry of signal collection, with excitation at 830 nm.
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Dates et versions

hal-00688280 , version 1 (17-04-2012)

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Donald Peyrot, Darine Abi Haidar, Claire Lefort, Nicolas Sandeau, Tigran Mansuryan, et al.. Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber. Endoscopic Microscopy VI, Nonlinear Endomicroscopy, Jan 2011, San franscisco - Californie, United States. pp.n°789309, ⟨10.1117/12.875440⟩. ⟨hal-00688280⟩
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