%0 Journal Article %T A deletion map of the human Y chromosome based on DNA hybridization. %+ Institut de génétique et microbiologie [Orsay] (IGM) %+ École Nationale Supérieure de Techniques Avancées (ENSTA Paris) %+ Biologie moléculaire des infections virales et cancérologie [Paris] %A Vergnaud, Gilles %A Page, David C. %A Simmler, Marie-Christine %A Brown, L %A Rouyer, François %A Noel, B %A Botstein, D %A de La Chapelle, Albert %A Weissenbach, Jean %< avec comité de lecture %@ 0002-9297 %J American Journal of Human Genetics %I Elsevier (Cell Press) %V 38 %N 2 %P 109-24 %8 1986-01-31 %D 1986 %M 3004206 %Z Life Sciences [q-bio]Journal articles %X The genomes of 27 individuals (19 XX males, two XX hermaphrodites, and six persons with microscopically detectable anomalies of the Y chromosome) were analyzed by hybridization for the presence or absence of 23 Y-specific DNA restriction fragments. Y-specific DNA was detected in 12 of the XX males and in all six individuals with microscopic anomalies. The results are consistent with each of these individuals carrying a single contiguous portion of the Y chromosome; that is, the results suggest a deletion map of the Y chromosome, in which each of the 23 Y-specific restriction fragments tested can be assigned to one of seven intervals. We have established the polarity of this map with respect to the long and short arms of the Y chromosome. On the short arm, there is a large cluster of sequences homologous to the X chromosome. The testis determinant(s) map to one of the intervals on the short arm. %G English %L hal-01160709 %U https://ensta-paris.hal.science/hal-01160709 %~ ENSTA %~ CNRS %~ UNIV-PSUD %~ I2BC %~ UNIV-PARIS-SACLAY %~ UNIV-PSUD-SACLAY %~ GS-HEALTH-DRUG-SCIENCES