Progress toward the total synthesis of mirabalin isomers
Résumé
Key fragments of the cytotoxic marine macrolide mirabalin have been synthesized, by using a flexible strategy
based on asymmetric reductions to control the hydroxy- and carbamate-bearing stereocenters. In particular,
ruthenium or rhodium-mediated asymmetric hydrogenation and transfer hydrogenation were used in
combination with a dynamic kinetic resolution to control two contiguous stereocenters in a single step.
Domaines
Chimie organique
Origine : Publication financée par une institution