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Article Dans Une Revue Lancet Oncology Année : 2018

Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study

Miranda Fidler
  • Fonction : Auteur
Murielle Colombet
  • Fonction : Auteur
Marion Piñeros
  • Fonction : Auteur
Rafael Peris-Bonet
  • Fonction : Auteur
Monika Hackl
  • Fonction : Auteur
Anna Zborovskaya
  • Fonction : Auteur
Nadya Dimitrova
  • Fonction : Auteur
Margit Mägi
  • Fonction : Auteur
Véronique Bouvier
  • Fonction : Auteur
Xavier Troussard
  • Fonction : Auteur
Anne-Sophie Woronoff
  • Fonction : Auteur
Emilie Marrer
  • Fonction : Auteur
Brigitte Trétarre
  • Fonction : Auteur
Marc Colonna
  • Fonction : Auteur
Olivier Ganry
Pascale Grosclaude
Berndt Holleczek
  • Fonction : Auteur
Zsuzsanna Jakab
  • Fonction : Auteur
Laufey Tryggvadóttir
  • Fonction : Auteur
Lucia Mangone
  • Fonction : Auteur
Franco Merletti
  • Fonction : Auteur
Stefano Ferretti
  • Fonction : Auteur
Bianca Caruso
  • Fonction : Auteur
Maria Michiara
  • Fonction : Auteur
Rosario Tumino
  • Fonction : Auteur
Fabio Falcini
  • Fonction : Auteur
Roberto Zanetti
  • Fonction : Auteur
Giovanna Tagliabue
  • Fonction : Auteur
Otto Visser
  • Fonction : Auteur
Giske Ursin
  • Fonction : Auteur
Ryszard Mężyk
  • Fonction : Auteur
Kamila Kepska
  • Fonction : Auteur
José Laranja Pontes
  • Fonction : Auteur
Maja Primic Žakelj
  • Fonction : Auteur
Rafael Fernández-Delgado
  • Fonction : Auteur
Marisa Vicente Raneda
  • Fonction : Auteur
Enrique Almar Marqués
  • Fonction : Auteur
José Ramón Quirós Garcia
  • Fonction : Auteur
Arantza Lopez de Munain
  • Fonction : Auteur
Rafael Marcos-Gragera
  • Fonction : Auteur
Maria-Jose Sanchez-Perez
  • Fonction : Auteur
Maria Ramos Monserrat
  • Fonction : Auteur
Eva Ardanaz
  • Fonction : Auteur
Jaume Galceran
  • Fonction : Auteur
Staffan Khan
  • Fonction : Auteur
Claudia Kuehni
  • Fonction : Auteur
Christine Bouchardy
  • Fonction : Auteur
Fabio Levi
  • Fonction : Auteur
Isabelle Konzelmann
  • Fonction : Auteur
Sabine Rohrmann
  • Fonction : Auteur
Sally Vernon
  • Fonction : Auteur
David Brewster
  • Fonction : Auteur
Ceri White
  • Fonction : Auteur
Anastasia Dolya
  • Fonction : Auteur

Résumé

Background: A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991-2010, we provide a consolidated report on cancer incidence trends at ages 0-19 years. Methods: We invited all population-based cancer registries operating in European countries to participate in this population-based registry study. We requested a listing of individual records of cancer cases, including sex, age, date of birth, date of cancer diagnosis, tumour sequence number, primary site, morphology, behaviour, and the most valid basis of diagnosis. We also requested population counts in each calendar year by sex and age for the registration area, from official national sources, and specific information about the covered area and registration practices. An eligible registry could become a contributor if it provided quality data for all complete calendar years in the period 1991-2010. Incidence rates and the average annual percentage change with 95% CIs were reported for all cancers and major diagnostic groups, by region and overall, separately for children (age 0-14 years) and adolescents (age 15-19 years). We examined and quantified the stability of the trends with joinpoint analyses. Findings: For the years 1991-2010, 53 registries in 19 countries contributed a total of 180 335 unique cases. We excluded 15 162 (8·4%) of 180 335 cases due to differing practices of registration, and considered the quality indicators for the 165 173 cases included to be satisfactory. The average annual age-standardised incidence was 137·5 (95% CI 136·7-138·3) per million person-years and incidence increased significantly by 0·54% (0·44-0·65) per year in children (age 0-14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4-178·0) per million person-years based on all 35 138 eligible cases and increased significantly by 0·96% (0·73-1·19) per year, although recent changes in rates among adolescents suggest a deceleration in this increasing trend. We observed temporal variations in trends by age group, geographical region, and diagnostic group. The combined age-standardised incidence of leukaemia based on 48 458 cases in children was 46·9 (46·5-47·3) per million person-years and increased significantly by 0·66% (0·48-0·84) per year. The average overall incidence of leukaemia in adolescents was 23·6 (22·9-24·3) per million person-years, based on 4702 cases, and the average annual change was 0·93% (0·49-1·37). We also observed increasing incidence of lymphoma in adolescents (average annual change 1·04% [0·65-1·44], malignant CNS tumours in children (average annual change 0·49% [0·20-0·77]), and other tumours in both children (average annual change 0·56 [0·40-0·72]) and adolescents (average annual change 1·17 [0·82-1·53]). Interpretation: Improvements in the diagnosis and registration of cancers over time could partly explain the observed increase in incidence, although some changes in underlying putative risk factors cannot be excluded. Cancer incidence trends in this young population require continued monitoring at an international level.
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hal-04031112 , version 1 (05-06-2024)

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Eva Steliarova-Foucher, Miranda Fidler, Murielle Colombet, Brigitte Lacour, Peter Kaatsch, et al.. Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study. Lancet Oncology, 2018, 19 (9), pp.1159-1169. ⟨10.1016/S1470-2045(18)30423-6⟩. ⟨hal-04031112⟩
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