Bone Morphogenetic Proteins Protect Pulmonary Microvascular Endothelial Cells From Apoptosis by Upregulating α-B-Crystallin - Université Pierre et Marie Curie Accéder directement au contenu
Article Dans Une Revue Arteriosclerosis, Thrombosis, and Vascular Biology Année : 2013

Bone Morphogenetic Proteins Protect Pulmonary Microvascular Endothelial Cells From Apoptosis by Upregulating α-B-Crystallin

Mariana Ciumas
  • Fonction : Auteur
Mélanie Eyries
  • Fonction : Auteur
Odette Poirier
  • Fonction : Auteur
Svetlana Maugenre
  • Fonction : Auteur
France Dierick
  • Fonction : Auteur
Natalia Gambaryan
  • Fonction : Auteur
Kevin Montagne
  • Fonction : Auteur
Florent Soubrier
  • Fonction : Auteur

Résumé

Objective— To investigate the role of bone morphogenetic proteins (BMPs) on α-B-crystallin ( CRYAB ) expression and its physiological consequences on endothelial cells (ECs). Approach and Results— We report that the gene encoding for the small heat shock protein, CRYAB , is a transcriptional target of the BMP signaling pathway. We demonstrate that CRYAB expression is upregulated strongly by BMPs in an EC line and in human lung microvascular ECs and human umbilical vein ECs. We show that BMP signals through the BMPR2-ALK1 pathway to upregulate CRYAB expression through a transcriptional indirect mechanism involving Id1. We observed that the known antiapoptotic effect of the BMPs is, in part, because of the upregulation of CRYAB expression in EC. We also show that cryab is downregulated in vivo, in a mouse model of pulmonary arterial hypertension induced by chronic hypoxia where the BMP pathway is downregulated. Conclusions— We demonstrate a cross-talk between BMPs and CRYAB and a major effect of this regulatory interaction on resistance to apoptosis.
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Dates et versions

hal-03783564 , version 1 (22-09-2022)

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Mariana Ciumas, Mélanie Eyries, Odette Poirier, Svetlana Maugenre, France Dierick, et al.. Bone Morphogenetic Proteins Protect Pulmonary Microvascular Endothelial Cells From Apoptosis by Upregulating α-B-Crystallin. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (11), pp.2577-2584. ⟨10.1161/ATVBAHA.113.301976⟩. ⟨hal-03783564⟩
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