Effectiveness of 2012–2013 influenza vaccine against influenza-like illness in general population - Université Pierre et Marie Curie Access content directly
Journal Articles Human Vaccines & Immunotherapeutics Year : 2014

Effectiveness of 2012–2013 influenza vaccine against influenza-like illness in general population

Abstract

Most of the methods used for estimating the influenza vaccine effectiveness (IVE) target the individuals who have an influenza-like illness (ILI) rather than virologically-proven influenza and access the healthcare system. The objective of this study was to estimate the 2012–2013 IVE in general French population, using a cohort of volunteers registered on GrippeNet.fr, an online surveillance system for ILI. The IVE estimations were obtained through a logistic regression, and analyses were also performed by focusing on at-risk population of severe influenza, and by varying inclusion period and ILI definition. Overall, 1996 individuals were included in the analyses. The corrected IVE was estimated to 49% (20 to 67) for the overall population, and 32% (0 to 58) for the at-risk population. Three covariables appeared with a significant effect on the occurrence of at least one ILI during the epidemic: the age (P = 0.045), the presence of a child in the household (P < 10−3), and the frequency of cold/flu (P < 10−3). Comparable results were found at epidemic peak time in the hypothesis of real-time feed of data. In this study, we proposed a novel, follow-up, web-based method to reveal seasonal vaccine effectiveness, which enables analysis in a portion of the population that is not tracked by the health care system in most VE studies.

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hal-03955605 , version 1 (25-01-2023)

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Marion Debin, Vittoria Colizza, Thierry Blanchon, Thomas Hanslik, Clement Turbelin, et al.. Effectiveness of 2012–2013 influenza vaccine against influenza-like illness in general population. Human Vaccines & Immunotherapeutics, 2014, 10 (3), pp.536-543. ⟨10.4161/hv.27439⟩. ⟨hal-03955605⟩
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