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Article Dans Une Revue ESAIM: Mathematical Modelling and Numerical Analysis Année : 2016

New transmission condition accounting for diffusion anisotropy in thin layer applied to diffusion MRI

Résumé

The Bloch-Torrey Partial Differential Equation (PDE) can be used to model the diffusion Magnetic Resonance Imaging (dMRI) signal in biological tissue. In this paper, we derive an Anisotropic Diffusion Transmission Condition (ADTC) for the Bloch-Torrey PDE that accounts for anisotropic diffusion inside thin layers. Such diffusion occurs, for example, in the myelin sheath surrounding the axons of neurons. This ADTC can be interpreted as an asymptotic model of order two with respect to the layer thickness and accounts for water diffusion in the normal direction that is low compared to the tangential direction. We prove uniform stability of the asymptotic model with respect to the layer thickness and a mass conservation property. We also prove the theoretical quadratic accuracy of the ADTC. Finally, numerical tests validate these results and show that our model gives a better approximation of the dMRI signal than a simple transmission condition that assumes isotropic diffusion in the layers.

Dates et versions

hal-01902194 , version 1 (23-10-2018)

Identifiants

Citer

Fabien Caubet, Houssen Haddar, Jing Rebecca Li, Dang Van Nguyen. New transmission condition accounting for diffusion anisotropy in thin layer applied to diffusion MRI. ESAIM: Mathematical Modelling and Numerical Analysis, 2016, 51, pp.1279--1301. ⟨10.1051/m2an/2016060⟩. ⟨hal-01902194⟩
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