We study the entanglement creation in the low-energy scattering of two particles in three dimensions, for a general class of interaction potentials that are not required to be spherically symmetric. The incoming asymptotic state, before the collision, is a product of two normalized Gaussian states. After the scattering, the particles are entangled. We take as a measure of the entanglement the purity of one of them. We provide a rigorous explicit computation, with error bound, of the leading order of the purity at low energy. The entanglement depends strongly on the difference of the masses. It takes its minimum when the masses are equal, and it increases rapidly with the difference of the masses. It is quite remarkable that the anisotropy of the potential gives no contribution to the leading order of the purity, in spite of the fact that entanglement is a second-order effect. © 2011 American Physical Society.