Recent human-specific spreading of a subtelomeric domain. - ENSTA Paris - École nationale supérieure de techniques avancées Paris Access content directly
Journal Articles Genomics Year : 1998

Recent human-specific spreading of a subtelomeric domain.


The recent spreading of a subtelomeric region at nine different human chromosome ends was characterized by a combination of segregation analyses, physical mapping, junction cloning, and FISH investigations. The events occurred very recently in human genome evolution as demonstrated by sequence analysis of different alleles and the single location of the ancestral site at chromosome 17qter in chimpanzee and orangutan. The domain successfully colonized most 1p, 5q, and 6q chromosome ends and is also present at a significant frequency of 6p, 7p, 8p, 11p, 15q, and 19p ends. On 6qter, the transposed domain is immediately distal to the highly conserved, single-copy gene PDCD2.
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hal-01160639 , version 1 (01-06-2020)



S Monfouilloux, H Avet-Loiseau, V Amarger, I Balazs, C Pourcel, et al.. Recent human-specific spreading of a subtelomeric domain.. Genomics, 1998, 51 (2), pp.165-76. ⟨10.1006/geno.1998.5358⟩. ⟨hal-01160639⟩
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