European Gene Mapping Project (EUROGEM): breakpoint panels for human chromosomes based on the CEPH reference families. Centre d'Etude du Polymorphisme Humain.
S A Cox
,
J Attwood
,
S P Bryant
,
R Bains
,
S Povey
(1)
,
M Rebello
,
M Kapsetaki
,
N K Moschonas
,
K H Grzeschik
(2)
,
M Otto
(2)
,
M Dixon
(3)
,
H E Sudworth
,
R F Kooy
(4)
,
A Wright
,
P Teague
,
L Terrenato
,
Gilles Vergnaud
(5, 6)
,
S Monfouilloux
,
J Weissenbach
(7)
,
O Alibert
(8)
,
C Dib
,
S Fauré
(9)
,
E Bakker
(10)
,
Nathaniel M. Pearson
(11, 12)
,
N K Spurr
1
University College
2 Human Genetics
3 Northeast Fisheries Science Center
4 Department of Medical Genetics, University Antwerp
5 IGM - Institut de génétique et microbiologie [Orsay]
6 ENSTA Paris - École Nationale Supérieure de Techniques Avancées
7 GENOSCOPE - Genoscope - Centre national de séquençage [Evry]
8 LEFG - Laboratoire d'Exploration Fonctionnelle des Génomes
9 SOPAM - Stress Oxydant et Pathologies Métaboliques
10 Haute Ecole Léonard de Vinci [Bruxelles]
11 Department of Ecology and Evolution [Chicago]
12 HHMI - Howard Hughes Medical Institute
2 Human Genetics
3 Northeast Fisheries Science Center
4 Department of Medical Genetics, University Antwerp
5 IGM - Institut de génétique et microbiologie [Orsay]
6 ENSTA Paris - École Nationale Supérieure de Techniques Avancées
7 GENOSCOPE - Genoscope - Centre national de séquençage [Evry]
8 LEFG - Laboratoire d'Exploration Fonctionnelle des Génomes
9 SOPAM - Stress Oxydant et Pathologies Métaboliques
10 Haute Ecole Léonard de Vinci [Bruxelles]
11 Department of Ecology and Evolution [Chicago]
12 HHMI - Howard Hughes Medical Institute
S A Cox
- Function : Author
J Attwood
- Function : Author
S P Bryant
- Function : Author
R Bains
- Function : Author
M Rebello
- Function : Author
M Kapsetaki
- Function : Author
N K Moschonas
- Function : Author
H E Sudworth
- Function : Author
A Wright
- Function : Author
P Teague
- Function : Author
L Terrenato
- Function : Author
Gilles Vergnaud
- Function : Author
- PersonId : 2910
- IdHAL : gilles-vergnaud
- ORCID : 0000-0003-0913-194X
- IdRef : 034239464
S Monfouilloux
- Function : Author
C Dib
- Function : Author
N K Spurr
- Function : Author
Abstract
Meiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 17, 18, 20 and X were constructed from genotypes from the CEPH reference families. Each recombinant chromosome included has a breakpoint well-supported with reference to defined quantitative criteria. The panels were constructed at both a low-resolution, useful for a first-pass localization, and high-resolution, for a more precise placement. The availability of such panels will reduce the number of genotyping experiments necessary to order new polymorphisms with respect to existing genetic markers. This paper shows only a representative sample of the breakpoints detected. The complete data are available on the World Wide Web (URL http:/(/)www.icnet.uk/axp/hgr/eurogem++ +/HTML/data.html) or by anonymous ftp (ftp.gene.ucl.ac.uk in/pub/eurogem/maps/breakpoints).