Polymers of random short oligonucleotides detect polymorphic loci in the human genome. - ENSTA Paris - École nationale supérieure de techniques avancées Paris Accéder directement au contenu
Article Dans Une Revue Nucleic Acids Research Année : 1989

Polymers of random short oligonucleotides detect polymorphic loci in the human genome.

Résumé

Polymers of random 14 mer oligonucleotides are shown to detect discrete loci in the human genome. Eighteen different synthetic tandem repeats of random 14 base-pair units (STRs) have been generated and all of them turn out to detect polymorphic loci on southern blots of human DNA samples, presumably corresponding to a variable number of tandem repeats (VNTR). This finding suggests that minisatellites are a major component of the human genome and are strongly associated with the generation of genetic variability. In addition, it should open new strategies to make new polymorphic probes available.

Dates et versions

hal-01160705 , version 1 (06-06-2015)

Identifiants

Citer

Gilles Vergnaud. Polymers of random short oligonucleotides detect polymorphic loci in the human genome.. Nucleic Acids Research, 1989, 17 (19), pp.7623-30. ⟨hal-01160705⟩
18 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More