A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.

Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.

Domains

Life Sciences [q-bio]

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https://ensta-paris.hal.science/hal-01160710

Submitted on : Saturday, June 6, 2015-5:53:41 PM

Last modification on : Wednesday, September 11, 2024-3:50:16 PM

Dates and versions

hal-01160710 , version 1 (06-06-2015)

Identifiers

HAL Id : hal-01160710 , version 1
DOI : 10.1038/319291a0
PUBMED : 3941746

Cite

François Rouyer, Marie-Christine Simmler, Christophe Johnsson, Gilles Vergnaud, Howard J. Cooke, et al.. A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.. Nature, 1986, 319 (6051), pp.291-5. ⟨10.1038/319291a0⟩. ⟨hal-01160710⟩